مجله‌ي بین المللی غدد درون‌ريز و متابوليسمInt J Endocrinol MetabMedical Scienceshttp://www.ijem.org1726-913XenThe Effect of the Change in the Definition of Type 2 Diabetes on Patient DemographicsTildesley HD^a,b, Wise JS^b, Mazanderani AB^a, Aydin CA^b, Fraser TS^b, Yu E^cTildesley HD<sup>ab</sup> Wise JS<sup>b</sup> Mazanderani AB<sup>a</sup> Aydin CA<sup>b</sup> Fraser TS<sup>b</sup> Yu E<sup>c</sup><sup>a</sup>Division of Endocrinology, St. Pauls Hospital, <sup>b</sup>Department of Medicine, and <sup>c</sup>Department of Statistics, University of British Columbia, Vancouver, British Colombia, CaOriginal ArticleIn 1998 the definition of type 2 diabetes was revised, in particular the fasting plasma glucose (FPG) diagnostic level was lowered from 7.8 mmol/L to 7.0 mmol/L. The purpose of this study was to examine the effects of this change on patient demographics. Materials &amp;amp;amp;amp; Methods: We reviewed data from 1700 type 2 diabetes patients, who attended the St. Paul’s Hospital Diabetes Teaching and Train-ing Centre before (group 1) and after (group 2) the definition change. Demographical data from a baseline and follow-up were analyzed. The frequencies of patients in groups and cohorts &amp;amp;amp;lt;60 years of age and ≥60 years of age were calculated and HbA1c data was analyzed. Results: Compared to Group 1, Group 2 was younger, had a significantly lower mean HbA1c level (7.3% vs 8.1%, p&amp;amp;amp;lt;0.0001), blood pressure (127/78 vs 133/82 mmHg, p&amp;amp;amp;lt;0.05) and cholesterol (5.2 vs 5.5 mmol, p&amp;amp;amp;lt;0.05) and was more often treated with multiple medications (p&amp;amp;amp;lt;0.001). Pa-tients in Group 2 were significantly more likely to meet the target HbA1c level of 7.0% than pa-tients in Group 1 (p&amp;amp;amp;lt;0.0001). It was also found that at baseline, patients ≥60 years old in Group 2 had significantly lower HbA1c values than those &amp;amp;amp;lt;60 years old (p&amp;amp;amp;lt;0.001). Conclusion: Since the change in the definition of type 2 diabetes, a greater frequency of patients presented with lower mean HbA1c values and met target HbA1c levels. Patients ≥60 years old initially presented with lower HbA1c levels than those &amp;amp;amp;lt;60 years old.Type 2 diabetes, Fasting plasma glucose, 1998 clinical practice guidelinesDefinition of type 2 diabetesHugh D. Tildesley8/18/2009 12:00:00 AM11/5/2009 12:00:00 AMhught@istar.ca275155http://www.ijem.org/Default.aspx